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DeCS
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Descriptor English:
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Cytochrome-B(5) Reductase
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Descriptor Spanish:
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Citocromo-B(5) Reductasa
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Descriptor Portuguese:
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Citocromo-B(5) Redutase
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Synonyms English:
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B5 Reductase, NADH-Cytochrome
Methemoglobin Reductase
Methemoglobin Reductase, NADH
NADH Cytochrome B5 Reductase
NADH Ferrihemoglobin Reductase
NADH Methemoglobin Reductase
NADH-Cytochrome B5 Reductase
NADH-Ferrihemoglobin Reductase
Reductase, Methemoglobin
Reductase, NADH Methemoglobin
Reductase, NADH-Ferrihemoglobin
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Tree Number:
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D08.811.682.608.191.237
D12.776.331.186
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Definition English:
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A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA. |
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Indexing Annotation English:
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/defic: consider also METHEMOGLOBINEMIA
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History Note English:
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2004; use CYTOCHROME B(5) REDUCTASE (NM) 1980-2003
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Allowable Qualifiers English:
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Record Number:
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38212
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Unique Identifier:
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D042966
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Occurrence in VHL:
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Similar:
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DeCS
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